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Percocet is a prescription medication that combines oxycodone, a potent opioid pain reliever, with acetaminophen, a non-opioid analgesic. It is prescribed for moderate to severe pain, such as post-surgical discomfort, injury-related pain, or chronic conditions when other treatments are insufficient. Oxycodone works by altering pain perception in the brain and spinal cord, while acetaminophen enhances pain relief and can help reduce fever.

Typical adult dosing depends on the formulation and medical evaluation. Immediate-release Percocet is usually prescribed at 2.5–10 mg of oxycodone with 325 mg of acetaminophen every 4–6 hours as needed, without exceeding the maximum daily acetaminophen limit. Extended-release forms may be taken once or twice daily for ongoing pain management under careful supervision. Percocet carries risks such as drowsiness, respiratory depression, dependence, and overdose, and alcohol or sedatives should be avoided. Safe and effective use requires adherence to a licensed healthcare provider’s instructions for dosage, timing, and monitoring of side effects.