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Percocet is a prescription medication combining oxycodone, an opioid pain reliever, with acetaminophen, a non-opioid analgesic. It is commonly prescribed for moderate to severe pain, especially after surgery, injury, or when other pain relievers are insufficient. Oxycodone works by changing the way the brain and nervous system perceive pain, while acetaminophen enhances pain relief and can reduce fever.

Typical adult dosing depends on the formulation and individual medical evaluation. Immediate-release Percocet tablets are often prescribed at 2.5 mg to 10 mg of oxycodone combined with 325 mg of acetaminophen every 4–6 hours as needed, with careful monitoring of acetaminophen intake to avoid liver toxicity. Extended-release forms may be taken once or twice daily under strict supervision. Because Percocet carries risks of drowsiness, respiratory depression, dependence, and overdose, it must be used exactly as prescribed. Alcohol and sedatives should be avoided, and regular follow-ups with a licensed healthcare provider ensure safe, effective pain management.